Background: Sepsis is the leading cause of mortality. Various scoring systems have been developed for its early identification and treatment. Study objective: To test the utility of quick sequential organ failure assessment (qSOFA) score to predict 7 and 28 days mortality in patients with suspected infection presenting to emergency department. Methods: We conducted a prospective study from July 2018 to April 2020. Consecutive patients with age ≥18 years who presented to the Emergency Department with a clinical suspicion of infection were included. Sensitivity, specificity, positive predictive value (PPV), negative predictive values (NPV), odds ratio (OR), areas under the receiver operating characteristics curve (AUROC) for sepsis related mortality on day 7 and 28 were measured. Results: 1200 patients were recruited out of which 65 patients lost to follow up. 54 (45.3%) out of 119 patients with positive qSOFA (qSOFA > 2) died at 7 days and 22 (18.4%) died at 28 days. 103 (10.3%) out of 1016 patients with negative qSOFA (qSOFA score < 2) died at 7 days and 104 (10.23%) died at 28 days. Patients with positive qSOFA score were at higher odds of dying at 7 days (OR: 3.9, 95%CI: 3.1 – 5, p < 0.001) and 28 days (OR: 1.9, 95% CI: 1.2 – 3.2, p < 0.001). The PPV and NPV with positive qSOFA score to predict 7 and 28 days mortality were 34%, 93% and 17%, 90% respectively. Conclusion: qSOFA score can be used as a risk stratification tool in a resource limited setting to identify infected patients at increased risk of death.